Our newest PREPRINT is out now, you can read it here :).
In this work, we show that exosome-enriched small extracellular vesicles (sEVs) provide lipid ligands for the CD1a-mediated T cell responses.
We also show that the reduced expression of critical skin barrier protein, filaggrin, in atopic dermatitis (AD) leads to the secretion of qualitatively different sEVs. These altered sEVs modulate T cell responses, reducing type 1 and promoting type 2 bias. This provides the basis for reduced tissue integrity and pathogen clearance and exacerbated allergic inflammation in the AD skin and potentially in distant tissues to which sEVs are transferred by systemic circulation.
